Risk of Early Adverse Events After Clopidogrel Discontinuation in Patients Undergoing Short-Term Dual Antiplatelet Therapy: An Individual Participant Data Analysis
JACC Cardiovasc Interv
; 10(16): 1621-1630, 2017. ilus, tab
Artigo
em Inglês
| Sec. Est. Saúde SP, SESSP-IDPCPROD, Sec. Est. Saúde SP
| ID: biblio-1064018
Biblioteca responsável:
BR79.1
Localização: BR79.1
ABSTRACT
OBJECTIVES:
The study sought to evaluate the presence of a clinically relevant rebound phenomenon after dual antiplatelet therapy (DAPT) discontinuation in randomized trials.BACKGROUND:
It is currently unknown whether clopidogrel discontinuation after short-term DAPT is associated with an early hazard of ischemic events.METHODS:
The authors performed an individual participant data analysis and aggregate meta-analysis. The primary outcome was major adverse cardiac and cerebrovascular events (MACCE), defined as the composite of cardiac death, myocardial infarction (MI), or stroke.RESULTS:
The study included 11,473 PCI patients with individual participant data from 6 randomized trials comparing short-term DAPT (3 or 6 months) versus long-term DAPT (12 months or more). During the first 90 days following clopidogrel discontinuation, there was no significant increase in the risk of MACCE between patients randomized to short-term DAPT compared with long-term DAPT (hazard ratio [HR] 1.18; 95% confidence interval [CI] 0.71 to 1.98; p»0.52; absolute risk difference 0.10%; 95% CI 0.16% to 0.36%). The risk of MI or stent thrombosis was similar among patients randomized to short-term DAPT versus long-term DAPT (HR 0.93; 95% CI 0.46 to 1.90; p»0.85). In the aggregate data meta-analysis of 11 trials including 38,919 patients, a higher risk of early MACCE was observed after long-term ($12 months) DAPT duration (HR 2.28; 95% CI 1.69 to 3.09; p<0.001) but not short-term (<12 months) DAPT duration (HR 1.08; 95% CI 0.67 to 1.74; p for interaction»0.036).CONCLUSIONS:
Among patients undergoing PCI with predominantly new-generation DES, discontinuation of clopidogrel after 3 or 6 months DAPT duration was not associated with an early increase in adverse clinical events. An early increase in MACCE was observed after long-term ($12 months) DAPT exposure.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
Sec. Est. Saúde SP
/
SESSP-IDPCPROD
Assunto principal:
Trombose Coronária
/
Reestenose Coronária
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Intervenção Coronária Percutânea
Tipo de estudo:
Ensaio clínico controlado
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Estudo de etiologia
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Fatores de risco
Limite:
Idoso
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Feminino
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Humanos
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Masculino
Idioma:
Inglês
Revista:
JACC Cardiovasc Interv
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
CHU de la Cavale Blanche/FR
/
Cardiovascular Center/KR
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Cardiovascular Research Foundation/US
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Heart and Vascular Center/US
/
Instituto Dante Pazzanese de Cardiologia/BR
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San Raffaele Scientific Institute/IT
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Severance Cardiovascular Hospital/KR
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University Hospital of Bern/CH
/
University of Bologna/IT