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Lower limb muscle strength and serotonin receptor gene polymorphism as factors associated in women with fibromyalgia
Lima, Luana Oliveira de; Zicarelli, Carlos Alexandre Martins; Matsumura, Andressa Saori; Moroti-Perugini, Layse Rafaela; Teixeira, Denilson de Castro; Fernandes, Karen Barros Parron; Perrucini, Priscila Daniele de Oliveira; Poli-Frederico, Regina Célia.
Afiliação
  • Lima, Luana Oliveira de; Rehabilitation Sciences State University of Londrina and University Pitágoras Unopar. Londrina. BR
  • Zicarelli, Carlos Alexandre Martins; Rehabilitation Sciences State University of Londrina and University Pitágoras Unopar. Londrina. BR
  • Matsumura, Andressa Saori; University Pitágoras Unopar. Biological and Health Sciences Center. Laboratory of Molecular Biology. Londrina. BR
  • Moroti-Perugini, Layse Rafaela; Rehabilitation Sciences State University of Londrina and University Pitágoras Unopar. Londrina. BR
  • Teixeira, Denilson de Castro; Londrina State University. Departament of Physical Education and Sport. Londrina. BR
  • Fernandes, Karen Barros Parron; Rehabilitation Sciences State University of Londrina and University Pitágoras Unopar. Londrina. BR
  • Perrucini, Priscila Daniele de Oliveira; Londrina State University. Departament of Physical Education and Sport. Londrina. BR
  • Poli-Frederico, Regina Célia; Rehabilitation Sciences State University of Londrina and University Pitágoras Unopar. Londrina. BR
Adv Rheumatol ; 59: 59, 2019. tab
Artigo em Inglês | LILACS | ID: biblio-1088616
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Background:

Fibromyalgia (FM) is a chronic pain syndrome characterized by generalized skeletal muscle chronic pain. Its etiology is not well defined, because there are several factors that may trigger it such as physical and/or emotional stresses, or a genetic susceptibility, involving serotonergic, dopaminergic and catecholaminergic paths. The objective of this study was to investigate the association between the strength of the lower limb, genetic polymorphism of the serotonin receptor gene HTR2a in women with fibromyalgia.

Methods:

In this observational study of case-control type 48 women were evaluated who belonged to the group with FM (52 ± 12 years) and 100 women in the control group (58±11 years). Socio demographic and anthropometric data were collected and peripheral blood samples for DNA extraction; genotypic analyzes were performed by means of PCR in real time by TaqMan® system. The lower limb muscle strength was assessed through the test of sitting down and standing up for 30 s. The chi-square test or Fischer Exact was used for possible associations among the variables; the t-test for independent samples was used to compare the averages among the groups; the value of significance adopted was 5%.

Results:

There was an association between the polymorphism of the HTR2A gene with FM, demonstrating that carriers of the genotype GG have 24.39 times more likely to develop the syndrome (IC95% 5.15-115.47; p = 0.01). It was observed an association between FM and the test to sit and stand up demonstrating that women with fibromyalgia have lower limb muscle strength ( p = 0.01). The study showed that the white race has 3.84 times more likely to develop FM (p = 0.01).

Conclusion:

The results of this study suggest that women of Caucasian ethnicity with GG genotype or G allele presented greater risk of developing fibromyalgia and that these patients have lower limb muscle strength compared to the control group.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Polimorfismo Genético / Fibromialgia / Força Muscular Tipo de estudo: Estudo observacional / Fatores de risco Limite: Feminino / Humanos Idioma: Inglês Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Londrina State University/BR / Rehabilitation Sciences State University of Londrina and University Pitágoras Unopar/BR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Polimorfismo Genético / Fibromialgia / Força Muscular Tipo de estudo: Estudo observacional / Fatores de risco Limite: Feminino / Humanos Idioma: Inglês Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Londrina State University/BR / Rehabilitation Sciences State University of Londrina and University Pitágoras Unopar/BR
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