Rhizopus-host interplay of disseminated mucormycosis in immunocompetent mice
s.l; s.n; 2020. 14 p. ilus.
Não convencional
em Inglês
| CONASS, Sec. Est. Saúde SP, SESSP-ILSLPROD, Sec. Est. Saúde SP, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1146950
Biblioteca responsável:
BR191.1
Localização: BR191.1; 9787/S
ABSTRACT
Aim:
To investigate the immune response of disseminated Ryzopus oryzae infection in immunocompetent mice.Methods:
C57Bl/6, BALB/c and Swiss wild-type mice were intravenously infected with R. oryzae; the parameters of infection and immune response were determined. Transcriptional signature of Th17 immune response and infection in Il17ra-/- mice were also evaluated.Results:
All mouse strains showed an initial spread of R. oryzae in the target tissues; however, after 30 days, C57Bl/6 and BALB/c mice showed an effective fungal clearance associated with specific production of IL-17 and IL-2. We also observed that 60% of Il17ra-/- mice succumbed to infection within 16 days.Conclusion:
This study has established an immunocompetent model for disseminated mucormycosis and highlighted the role of IL-17 signaling in immunity against R. oryzae(AU).
Buscar no Google
Coleções:
Bases de dados nacionais
/
Brasil
Base de dados:
CONASS
/
Sec. Est. Saúde SP
/
SESSP-ILSLACERVO
/
SESSP-ILSLPROD
Assunto principal:
Rhizopus
/
Imunocompetência
/
Mucormicose
Limite:
Animais
Idioma:
Inglês
Ano de publicação:
2020
Tipo de documento:
Não convencional