Your browser doesn't support javascript.
loading
Efficacy of autologous platelet-rich plasma gel in the treatment of refractory pressure injuries and its effect on wound healing time and patient quality of life
Liu, Qian; Zhang, Ning; Li, Zhengnan; He, Hongmei.
Afiliação
  • Liu, Qian; Ganzhou Peoples Hospital. Department of Sports Medicine. Ganzhou. CN
  • Zhang, Ning; Ganzhou Peoples Hospital. Department of Gastroenterology. Ganzhou. CN
  • Li, Zhengnan; Ganzhou Peoples Hospital. Department of Sports Medicine. Ganzhou. CN
  • He, Hongmei; Ganzhou Peoples Hospital. Department of Gastroenterology. Ganzhou. CN
Clinics ; Clinics;76: e2355, 2021. tab, graf
Article em En | LILACS | ID: biblio-1153933
Biblioteca responsável: BR1.1
ABSTRACT

OBJECTIVES:

To evaluate the efficacy of autologous platelet-rich plasma (PRP) gel in the treatment of refractory pressure injuries and its effect on wound healing time and quality of life of patients.

METHODS:

A random number table method was used to group 102 patients with refractory pressure injuries into either a control group (CG) (51 cases) receiving negative pressure wound therapy (NPWT) or a study group (SG) (51 cases) receiving NPWT+PRP gel.

RESULTS:

The total efficacy rate in the SG (92.16%) was higher than that in the CG (76.47%) (p<0.05). The SG exhibited lower visual analog scale (VAS) scores and pressure ulcer scale for healing (PUSH) scores, smaller wound sizes and depths, and shorter wound healing times than the CG after 21 days of treatment (p<0.05). After 6 months of treatment, the SG scored higher than the CG on the psychological, physiological, social functions, and daily activity domains on the World Health Organization Quality of Life (WHOQOL-BREF) scale (p<0.05). The incidence of postoperative complications in the SG (13.73%) was not significantly different from that of the CG (7.84%) (p>0.05).

CONCLUSION:

In the treatment of refractory pressure injuries, PRP gel can accelerate wound healing, reduce wound pain, shorten the treatment cycle, regulate tissue inhibitor matrix metalloproteinase-1 (TIMP-1) and matrix metalloproteinase-9 (MMP-9) levels and the expression of specific proteins in granulation tissue, reduce the levels of the inflammatory factors interleukin-1β (IL-1β), IL-8, and tumor necrosis factor-α (TNF-α), and improve the quality of life of patients without increasing complications.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Úlcera por Pressão / Plasma Rico em Plaquetas / Tratamento de Ferimentos com Pressão Negativa Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Úlcera por Pressão / Plasma Rico em Plaquetas / Tratamento de Ferimentos com Pressão Negativa Aspecto: Patient_preference Limite: Humans Idioma: En Revista: Clinics Assunto da revista: MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Brasil