Avances en el tratamiento de las ataxias crónicas / [Therapeutic developments in chronic ataxias].
Medicina (B.Aires)
; 73 Suppl 1: 49-54, 2013.
Artigo
em Espanhol
| LILACS, BINACIS
| ID: biblio-1165148
Biblioteca responsável:
AR5.1
Localização: [{"text": "AR5.1"}]
ABSTRACT
Autosomal recessive cerebellar ataxias belong to a broader group of disorders known as inherited ataxias. In most cases onset occurs before the age of 20. These neurological disorders are characterized by degeneration or abnormal development of the cerebellum and spinal cord. Currently, specific treatment is only available for some of the chronic ataxias, more specifically those related to a known metabolic defect, such as abetalipoproteinemia, ataxia with vitamin E deficiency, and cerebrotendinous xanthomatosis. Treatment based on a diet with reduced intake of fat, supplementation of oral vitamins E and A, and the administration of chenodeoxycholic acid could modify the course of the disease. Although for most of autosomal recessive ataxias there is no definitive treatment, iron chelators and antioxidants have been proposed to reduce the mitochondrial iron overload in Friederichs ataxia patients. Corticosteroids have been used to reduce ataxia symptoms in ataxia telangiectasia. Coenzyme Q10 deficiency associated with ataxia may be responsive to Co Q10 or ubidecarenone supplementations. Early treatment of these disorders may be associated with a better drug response.
Buscar no Google
Coleções:
Bases de dados internacionais
Base de dados:
BINACIS
/
LILACS
Assunto principal:
Ataxia Cerebelar
Tipo de estudo:
Estudo de etiologia
Idioma:
Espanhol
Revista:
Medicina (B.Aires)
Assunto da revista:
Medicina
Ano de publicação:
2013
Tipo de documento:
Artigo