Expression of VEGF-A, HIF-1 A, CD34 and Ki67 in clear cell renal cell carcinomas and their relationship with conventional prognostic markers / Expression of VEGF-A, HIF-1 A, CD34 and Ki67 in clear cell renal cell carcinomas and their relationship with conventional prognostic markers.
Rev. Fac. Cienc. Méd. (Córdoba)
; 71(1): 7-15, 2014.
Artigo
em Espanhol
| LILACS, BINACIS
| ID: biblio-1170973
Biblioteca responsável:
AR5.1
Localização: [{"text": "AR5.1"}]
ABSTRACT
Clear cell renal carcinoma is the most frequent type of renal carcinoma. Recently, attention has been focused in the expression of angiogenic factors by these tumors, which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those patients with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of clear cell renal cell carcinoma were studied. Clinical and pathological data were collected. Tumors were studied to assess immunohistochemical expression of the following markers VEGF-A, HIF-1α, CD34 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of HIF-1α was directly related to Furhman grade, invasion of the renal vein and tumor stage. Likewise, tumor proliferation index, assessed with Ki67, was directly related to the presence of necrosis, capsular invasion and advanced tumor stage. Regarding the expression of CD34, vascular density was inversely related to tumor necrosis and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in tumor evolution and prognostic evaluation of these tumors.
Buscar no Google
Coleções:
Bases de dados internacionais
Base de dados:
BINACIS
/
LILACS
Assunto principal:
Carcinoma de Células Renais
/
Fator A de Crescimento do Endotélio Vascular
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
/
Neoplasias Renais
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Espanhol
Revista:
Rev. Fac. Cienc. Méd. (Córdoba)
Assunto da revista:
Medicina
Ano de publicação:
2014
Tipo de documento:
Artigo