PGL-1 antigen and antibody detection in leprosy patients: evolution under chemotherapy
Int. j. lepr. other mycobact. dis
; 57(4): 735-743, dec. 1989. tab
Artigo
em Inglês
| Sec. Est. Saúde SP, HANSEN, Hanseníase, SESSP-ILSLACERVO, Sec. Est. Saúde SP
| ID: biblio-1226461
Biblioteca responsável:
BR191.1
Localização: [{"text": "Br191.1"}]
RESUMO
Multibacillary (MB) and paucibacillary (PB) leprosy patients were tested for circulating phenolic glycolipid-I (PGL-I) antigen and antibodies before treatment. In the 27 MB patients tested, 27 (100%) were antigen positive with levels ranging from 50 to 5000 ng/ml, and 26 (96%) were antibody positive with titers ranging from 1000 to 64,000. Although the antigen and antibody levels were much higher in MB than in PB patients, we could not demonstrate a correlation between the number of acid-fast bacilli/mg of skin biopsy and these two parameters in 14 MB patients. After starting daily multidrug therapy, 10 MB patients were monitored monthly. As much as 88.75% +/- 10.8% of the PGL-I antigen was cleared from the bloodstream after 1 month while the anti-PGL-I antibody remained stable. This rapid decrease in the PGL-I antigen level strongly suggests the usefulness of this test for monitoring MB patients under chemotherapy
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Brasil
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Hanseníase
/
Doenças Negligenciadas
Base de dados:
HANSEN
/
Hanseníase
/
Sec. Est. Saúde SP
/
SESSP-ILSLACERVO
Assunto principal:
Dapsona
/
Anticorpos Antibacterianos
/
Antígenos de Bactérias
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Revista:
Int. j. lepr. other mycobact. dis
Ano de publicação:
1989
Tipo de documento:
Artigo
Instituição/País de afiliação:
Institut Pasteur/PF