Vitamin D Levels and Insulin Resistance among Nigerian men with Type-2 Diabetes mellitus
Ann. Health Res. (Onabanjo Univ. Teach. Hosp.)
; 2(1): 10-16, 2016. tab
Artigo
em Inglês
| AIM (África)
| ID: biblio-1258785
Biblioteca responsável:
CG1.1
ABSTRACT
Background:
A number of studies have shown a high prevalence of insufficient vitamin D levels in humans in the North American, European and Asian regions. Various research works have also shown that low serum vitamin D levels play a major role in the pathogenesis of chronic, non-infective illnesses such as diabetes mellitus and cancer.Objective:
This study was aimed at assessing the serum vitamin D status in relation to glucose homeostasis among men with Type-2 Diabetes mellitus and normal controls.Methods:
This comparative cross-sectional study included 80 men with confirmed diagnosis of Type-2 diabetes mellitus and 49 normal adult male controls. Serum 25-hydroxy vitamin D, fasting serum C-peptide and fasting plasma glucose levels were measured in both study groups.Results:
There was a significant difference between the mean serum 25-OH vitamin D levels among the cases (36.55ng/mL) and the controls (42.96ng/mL) (p = 0.001). All the four 25-OH vitamin D-deficient subjects had diabetes. In the diabetes group, 43.8% had a normal insulin resistance compared to 61.8% of the control group (p = 0.054). In the diabetes group, 73.8% had sufficient vitamin D, 21.2% had insufficient vitamin D and 5% had vitamin D deficiency. In the control group, there was a significant negative correlation between serum 25-OH vitamin D and BMI and fasting plasma glucose. The mean HOMA2IR value for the diabetes group (3.09) was higher than the value for the controls (2.40).Conclusion:
The mean serum 25-OH vitamin D level in the diabetes group was lower than that of the control group hence, hypovitaminosis D may be a contributor to the onset of diabetes mellitus among Nigerian men
Texto completo:
Disponível
Base de dados:
AIM (África)
Assunto principal:
Peptídeo C
/
Resistência à Insulina
/
Estudos Transversais
/
Nigéria
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
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Fatores de risco
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Ann. Health Res. (Onabanjo Univ. Teach. Hosp.)
Ano de publicação:
2016
Tipo de documento:
Artigo