Acquired nephrogenic diabetes insipidus complicating acute tubular necrosis with acute renal failure

ABSTRACT

Two cases of acquired nephrogenic diabetes insipidus following acute tubular necrosis with acute renal failure due to severe intravascular hemolysis are presented. One of the cases was associated with full defect of Glucose 6-Phosphate Dehydrogenase (G6PD) with mild falciparum malaria parasitaemia. Both cases had prolonged polyuria even when their electrolytes; urea and creatinine levels had normalised. Water deprivation tests showed inability to concentrate the urine in both cases. It was only when oral intake was reduced that urine volumes normalised. It is suggested that such cases be controlled with judicious fluid restriction rather than keeping up with fluid losses