Antimicrobial Resistance in Outpatient Escherichia coli Urinary Isolates in Dakar; Senegal
J. infect. dev. ctries
; 1(3): 263-268, 2007.
Artigo
em Inglês
| AIM (África)
| ID: biblio-1263546
Biblioteca responsável:
CG1.1
ABSTRACT
Background:
Data regarding the evolution of antimicrobial resistance are needed to suggest appropriate empirical treatment of urinary tract infections (UTI) in developing countries. To assess the antimicrobial susceptibility of Escherichia coli; the predominant pathogen in community-acquired UTI; a prospective multicenter study was carried out in Dakar; Senegal.Methodology:
From February 2004 to October 2006; 1010 non-duplicate E. coli strains were collected from four centres. Antimicrobial susceptibility testing was performed using disk diffusion method according to the recommendations of the CA-SFM (2004).Results:
Most of the isolates were resistant to amoxicillin (73.1); amoxicillin- clavulanic acid (67.5); cephalothin (55.8); and trimethoprim/sulfamethoxazole (68.1). Extended spectrum beta-lactamase was detected in 38 strains. The overall resistance rates to nalidixic acid; norfloxacin and ciprofloxacin were 23.9; 16.4and 15.5; respectively. Most of the strains were susceptible to gentamicin; nitrofurantoin and fosfomycin (respective susceptibility rates; 93.8; 89.9; and 99.3). During this period; a significant decrease in sensitivity was observed for cephalothin; fluoroquinolones and trimethoprim/sulfamethoxazole (p0.001).Conclusions:
These data suggest that trimethoprim/sulfamethoxazole may no longer be used as empirical treatment for community- acquired UTI in Dakar. In order to preserve the activity of fluoroquinolones for future years; alternatives such as fosfomycin or nitrofurantoin should be considered
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Zoonoses
Base de dados:
AIM (África)
Assunto principal:
Pacientes Ambulatoriais
/
Infecções Urinárias
/
Resistência a Medicamentos
/
Escherichia coli
Tipo de estudo:
Ensaio clínico controlado
/
Guia de prática clínica
Idioma:
Inglês
Revista:
J. infect. dev. ctries
Ano de publicação:
2007
Tipo de documento:
Artigo