Epidemiology of Antimicrobial Resistance in pathogens Isolated in Mulago Hospital in 1998 and 2000

RESUMO

This study analysed the antimicrobial resistance distribution of Staphylococcus; Enterobacteria; Haemophillus and Pseudomonas isolated from the common service departments in Mulago Hospital; over periods of 1998 and 2000. The Standard Errors (se) of two proportions (resistance) and 95Confidence Interval (CI) for the difference between two proportions were used as statistical tests for determining whether there were changes being experienced over the study period. The analysed agents such as Methicillin; Etythromycine and Ceftazidime did not change in resistance point prevalence mechanisms that do not modify or attack them. While Augumentin; Sodium Cefuroxime; Chloramphenicol; Ciprofoxacin; Gentamicin; Tetracycline and Nitrofurantoin showed icnreased resistance prevalence (P0.05 possibly because of being overused or modified by many resistance mechanisms; high rates of resistance were seen in Enterobacteria (67); Staphylococcus (62) and haemophilus (50). Antipseudomonal agents did not show change in resistance prevalence (P0.05). Departmental/ward distribution of resistant isolates did not also change; except in Emergency and Outpatient departments since bacterial ecology tends to keep constant unless contronted by high level of infection control practice