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Adenovirus-associated pneumonia in South African children: Presentation, clinical course and outcome
Zampoli, M; Mukuddem-Sablay, Z.
Afiliação
  • Zampoli, M; s.af
  • Mukuddem-Sablay, Z; s.af
S. Afr. med. j. (Online) ; 107(2): 123-126, 2017. tab
Artigo em Inglês | AIM (África) | ID: biblio-1271148
Biblioteca responsável: CG1.1
ABSTRACT
Background. Viruses have emerged as important aetiological agents of childhood pneumonia.Objective. To investigate the clinical presentation, severity and outcome of adenovirus-associated pneumonia (AVP) in children.Methods. A retrospective analysis of AVP cases over 12 months was performed, including demographic, clinical course and outcome (death, persistent lung disease (PLD)) data.Results. Two hundred and six AVP cases (median age 12 months, interquartile range 6 - 24) were identified; 70 children (34.0%) were malnourished and 14 (6.8%) were HIV-infected. Twenty-nine children (14.1%) developed PLD, which was associated with hypoxia at presentation in 26 cases (89.7%; p=0.01) and necessitated admission to the intensive care unit (ICU) in 18 (62.1%; p<0.01); 18/206 children (8.7%) died. Admission to the ICU (odds ratio (OR) 8.3, 95% confidence interval (CI) 2.3 - 29.0) and a positive blood culture (OR 11.2, 95% CI 2.3 - 54.1) were independent risk factors for mortality.Conclusions. Adenovirus is a potential cause of pneumonia and PLD in young children in South Africa. ICU admission and a positive blood culture were associated with poor

outcome:

Assuntos
Texto completo: Disponível Base de dados: AIM (África) Assunto principal: Pneumonia / Infecções por Adenovirus Humanos / Criança / Pneumopatias Obstrutivas Tipo de estudo: Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: S. Afr. med. j. (Online) Ano de publicação: 2017 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: AIM (África) Assunto principal: Pneumonia / Infecções por Adenovirus Humanos / Criança / Pneumopatias Obstrutivas Tipo de estudo: Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: S. Afr. med. j. (Online) Ano de publicação: 2017 Tipo de documento: Artigo
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