D-dimer levels as marker of deep vein thrombosis in patients with cervical cancer: A study of a northern Nigerian patient population
Sahel medical journal (Print)
; 22(2): 86-91, 2019. ilus
Article
em En
| AIM
| ID: biblio-1271709
Biblioteca responsável:
CG1.1
ABSTRACT
Background:
Cervical cancer is the most common genital tract malignancy in Nigeria and an important cause of cancerrelated death in women. Patients with advanced cervical cancer are often victims of deep venous thrombosis (DVT) that increases morbidity and mortality. Strategies at screening and early diagnosis enable prompt treatment which improves quality of life.Objectives:
The objective of this study is to determine the plasma Ddimer level in patients with cervical cancer and its relationship to the presence of DVT,Well's score, and stage of malignancy. Materials andMethods:
It is a prospective cross-sectional descriptive study of patients with histological diagnosis of cervical cancer in a Nigerian population. Patients' clinical, laboratory, and radiological data were obtained, and their body mass index (BMI) was calculated. Well's chart 17 was used to categorize patients using a cutoff of 2. Plasma Ddimer was quantified by immunoturbidimetric method and interpreted as significant if >0.099 g/dl.Highresolution ultrasound with 510 MHZ linear probe was used to evaluate the lower limbs veins of the patients. Data were analyzed with SPSS version 20. The test of association was done using Chisquare with a P < 0.05 considered statistically significant.Results:
A total of 77 patients were enrolled, but 67 patients had complete data. The mean age was 54.7 ± 11.2 years. The average parity was 7.5 ± 3.1. Majority (47.8%) had normal BMI. Ddimer was positive in 58 (87%). Of the 17 (25%) with both elevated Ddimer and high probability of DVT, 5 (29%) had DVT. The incidence of DVT among our study population was 7.5%. There was statistically significant relationship between stage of diseaseand an elevated Ddimer value (Ï2 = 5.82, α = 0.016, 95% confidence interval).Conclusion:
Deep vein thrombosis occurred only in patients with high Ddimer and high Well's score, which makes their combination relevant in early diagnosis. Advanced age, high parity advanced stage of disease was the main associated risk factors. All cases with DVT occurred in patients with squamous cell cancer
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Base de dados:
AIM
Assunto principal:
Trombose
/
Neoplasias do Colo do Útero
/
Trombose Venosa
/
Nigéria
Tipo de estudo:
Risk_factors_studies
/
Screening_studies
Aspecto:
Patient_preference
País/Região como assunto:
Africa
Idioma:
En
Revista:
Sahel medical journal (Print)
Ano de publicação:
2019
Tipo de documento:
Article