Physicochemical Analysis of the Aqueous Extracts of Six Nigerian Medicinal Plants
Trop. j. pharm. res. (Online)
; 9(2): 119-125, 2010.
Artigo
em Inglês
| AIM (África)
| ID: biblio-1273132
Biblioteca responsável:
CG1.1
ABSTRACT
Purpose:
Extracts of Picralima nitida seeds; Detarium microcarpum stem bark; Aframomum melagueta seeds; Terminalia catappa leaves; Acacia nilotica pods; and Morinda lucida stem bark; are under consideration for development into suitable dosage forms for treating diabetes mellitus; sickle cell anemia and malaria. This study aimed at evaluating the extracts for features that would influence decisions on them in the course of the project.Methods:
Physicochemical determinations; including proximate analysis; were done by sensory examination; and gravimetric and electrochemical techniques. Thin layer chromatography was carried out with normal silica plates using various solvent systems. Metallic content analyses were carried out by atomic absorption spectroscopy.Results:
The extracts were dry but hygroscopic; with a loss on drying range of 0.26 - 12.00w/w. The pH of the 5 - 10solutions ranged 5 - 7. No harsh sensory effects; such as lacrimation; were detected in any of the extracts. Total ash ranged from 3.79 - 20.68w/w; while acid insoluble ash values were below detection. The extracts yielded reproducible chromatograms on normal silica plates developed with various solvent systems. Copper; present at 0.16 - 0.58 mg/100g; was the lowest occurring microelement while calcium content was highest; at 41 - 216 mg/100g. The level of lead; a heavy metal; was 0.05 - 0.22 mg/100g.Conclusion:
The results confirm that the extracts require no special handling; possess characteristics that would allow their possible development into solid dosage forms; and that their lead contents complied with official limits
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Malária
Base de dados:
AIM (África)
Assunto principal:
Plantas
/
Extratos Vegetais
/
Terminalia
/
Zingiberaceae
/
Morinda
/
Acacia
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Trop. j. pharm. res. (Online)
Ano de publicação:
2010
Tipo de documento:
Artigo