Changes in Total and Differential white Cell Counts; Total Lymphocyte and CD4 Cell Counts during the Menstrual Cycle in Healthy Female Undergraduate Students in Port Harcourt; Nigeria
port harcourt med. J
; 6(1): 2-9, 2011.
Artigo
em Inglês
| AIM (África)
| ID: biblio-1274174
Biblioteca responsável:
CG1.1
RESUMO
Background:
Published reports on the possible changes in the various immune cell populations; especially the total lymphocyte and CD4 cell counts; during the menstrual cycle in Nigerian female subjects are relatively scarce.Aim:
To determine possible changes in the total and differential white blood cell [WBC] counts; total lymphocyte count [TLC] and CD4 cell count during the menstrual cycle in apparently healthy reproductive aged female undergraduate students in Port Harcourt; Nigeria.Methods:
A total of 61 apparently healthy HIV sero-negative female undergraduate students of the University of Port Harcourt; Nigeria aged between 17 and 30 years; were recruited into the study. Subjects were allowed their normal daily routines but restricted from excessive physical activities for the duration of the study. After a menstrual history; blood was collected from each subject at the different phases of the menstrual cycle menstrual; follicular; ovulatory and luteal. Total WBC and differential counts were determined manually; TLC was obtained by multiplying the percentage lymphocytes by the total WBC count; CD4 cell counts were determined by flow cytometry.Results:
Single factor analysis of variance showed significant differences only in the values of total WBC; and differential neutrophils; lymphocytes; and eosinophil counts [p0.05]; no significant differences were observed in the values of monocytes; basophils; TLC and CD4 cell count during the phases of the menstrual cycle.Conclusion:
The present study confirms previous reports of significant physiological variations in the leukocyte counts during the phases of the normal menstrual cycle. However; our results suggest that apparently TLC and CD4 cell count do not undergo a similar physiological variation
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Base de dados:
AIM (África)
Assunto principal:
Estudantes
/
Saúde da Mulher
/
Leucócitos
/
Ciclo Menstrual
Idioma:
Inglês
Revista:
Port harcourt med. J
Ano de publicação:
2011
Tipo de documento:
Artigo