Estimation of malaria-attributable fever in malaria testpositive febrile outpatients in three provinces of mozambique, 2018
Am. j. trop. med. hyg
; 102(1): 151-155, 2020. Tab
Artigo
em Inglês
| RDSM
| ID: biblio-1348724
Biblioteca responsável:
MZ1.1
ABSTRACT
Like most malaria-endemic countries, Mozambique relies on tabulation of confirmed malaria testpositive febrile patients to track incidence of malaria. However, this approach is potentially biased by incidental malaria parasitemia in patients with fever of another etiology. We compared pan-Plasmodium aldolase and lactate dehydrogenase and Plasmodium falciparum histidine-rich protein 2 (PfHRP2) antigen concentrations measured using a laboratory bead-based assay of samples collected from 1,712 febrile and afebrile patients of all ages in Maputo, Zambézia, and Cabo Delgado provinces. We used a Bayesian latent class model to estimate the proportion of malaria-attributable fevers in malaria testpositive febrile patients. Depending on the antigen, estimated rates of malaria-attributable fever in malaria testpositive febrile patients were 100% in Maputo, 3358% in Zambézia, and 6374% in Cabo Delgado. Our findings indicate that most malaria testpositive febrile patients in the three provinces of Mozambique had a fever that was likely caused by the concurrent malaria infection. Counting malaria testpositive febrile patients for estimation of malaria incidence appears to be appropriate in this setting.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Moçambique
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Malária
/
Doenças Negligenciadas
Base de dados:
RDSM
Assunto principal:
Febre
/
Malária
/
Antígenos de Protozoários
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Am. j. trop. med. hyg
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Clinton health accessinitiative/MZ
/
Malaria Branch, divisionof parasitic diseases and malaria, centerfor global health, centers for disease control and prevention/GE
/
National malaria control program, ministry of health/MZ
/
Swiss tropical and public heal thinstitute, Base/CH