High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome
Epigenomics (Online)
; 13(6): 423-436, Mar. 2021. ilus
Article
em En
| CONASS, SES-SP, SESSP-IDPCPROD, SES-SP
| ID: biblio-1354234
Biblioteca responsável:
BR79.1
ABSTRACT
ABSTRACT To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients with metabolic syndrome (MetS). METHODS:
Serum levels of 372 miRNAs were measured in patients with (n = 6) and without MetS (n = 6) by quantitative PCR array, and dysregulated miRNAs were validated in a larger cohort (MetS, n = 89; non-MetS, n = 144).RESULTS:
In the screening study, seven miRNAs were dysregulated in patients with MetS, and miR-421 remained increased in the validation study. miR-421 was associated with a high risk of MetS and insulin resistance and hypertension and correlated with glycated hemoglobin, triacylglycerols, high-sensitivity CRP, IL-6, resistin and adiponectin (p < 0.05).CONCLUSION:
Circulating miR-421 is a potential biomarker for insulin resistance, metabolic dysregulation and inflammatory status in patients with MetS.
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Coleções:
06-national
/
BR
Base de dados:
CONASS
/
SES-SP
/
SESSP-IDPCPROD
Assunto principal:
Síndrome Metabólica
/
Adiponectina
/
Adiposidade
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Revista:
Epigenomics (Online)
Ano de publicação:
2021
Tipo de documento:
Article