Pain management & opioid dose reduction with topical sevoflurane instillations in intractable venous ulcers: a case report
Braz. J. Pharm. Sci. (Online)
; 58: e18681, 2022. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1360162
Biblioteca responsável:
BR40.1
Localização: BR40.1
ABSTRACT
Abstract Vascular ulcers (VU) constitute a major cause of pain and disability, and significantly compromise quality of life. VU have a natural tendency to become chronic and in many cases exhibit anunsatisfactoryresponse to many of the standard therapeutic options.The case of a 73 year-old Caucasian female with severe pain and poorly-controlled pain (Visual Analogic Scale-VAS- of 8-9) due to three lower leg long-standing VUs is reported and discussed herein. The patient was treated with topical instillations of undiluted sevoflurane as per institutional off-label protocol (starting doses of 1mL/cm2 twice a day, and up-titrated according to response to a maximum of 7 mL twice daily). The VAS score dropped to 0-1 shortly after initiation of therapy and remained stable throughout treatment up until the closure of the observations. Subsequently, opioid therapy was gradually tapered down and ultimately abandoned.Sevoflurane application resulted on adequate and sustained pain management of refractory VU, with no significant side effects. On account of its beneficial effectivity and safety profiles, topical sevoflurane emerges as an add-on alternative for the long-term management of VU, and potentially other painful conditions.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
/
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
Problema de saúde:
Objetivo 9: Redução de doenças não transmissíveis
/
Meta 3.4: Reduzir as mortes prematuras devido doenças não transmissíveis
/
Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
/
Abuso de Opioides
Base de dados:
LILACS
Assunto principal:
Dor
/
Úlcera Varicosa
/
Relatório de Pesquisa
/
Sevoflurano
/
Redução da Medicação
/
Analgésicos Opioides
Tipo de estudo:
Guia de prática clínica
Aspecto:
Preferência do paciente
Limite:
Idoso
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Espanha
Instituição/País de afiliação:
Public Health Agency of Poniente/ES
/
Torrecárdenas University Hospital/ES