Investigation of therapeutic effects in the wound healing of chitosan/pGM-CSF complexes
Braz. J. Pharm. Sci. (Online)
; 58: e19668, 2022. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1383976
Biblioteca responsável:
BR40.1
Localização: BR40.1
ABSTRACT
Abstract Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing studies. The aim of this study was to investigate the in vitro proliferative effects of chitosan/pGM-CSF complexes as well as the therapeutic role of the complexes in an in vivo rat wound model. The effect of complexes on cell proliferation and migration was examined. Wounds were made in Wistar-albino rats, and examined histopathologically. The cell proliferation and migration were increased weight ratio- and time-dependently in HaCaT and NIH-3T3 cell lines. Wound healing was significantly accelerated in rats treated with the complexes. These results showed that the delivery of pGM-CSF using chitosan complexes could play an accelerating role in the cell proliferation, migration, and wound-healing process.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Terapêutica
/
Cicatrização
/
Ferimentos e Lesões
/
Usos Terapêuticos
/
Quitosana
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Inönü University/TR
/
Inönü University/TR
/
Izmir Atatürk Education and Research Hospital/TR
/
Marmara University/TR
/
Medipol University/TR
/
University of Health Sciences/TR