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Increased incidence of candidemia in critically ill patients during the Coronavirus Disease 2019 (COVID-19) pandemic
Papadimitriou-Olivgeris, Matthaios; Kolonitsiou, Fevronia; Kefala, Sotiria; Spiliopoulou, Anastasia; Aretha, Diamanto; Bartzavali, Christina; Siapika, Argyro; Marangos, Markos; Fligou, Fotini.
Afiliação
  • Papadimitriou-Olivgeris, Matthaios; University of Patras. Division of Infectious Diseases, School of Medicine. Patras. GR
  • Kolonitsiou, Fevronia; University of Patras. Department of Microbiology, School of Medicine. Patras. GR
  • Kefala, Sotiria; University of Patras. Division of Anaesthesiology and Intensive Care Medicine, School of Medicine. Patras. GR
  • Spiliopoulou, Anastasia; University of Patras. Department of Microbiology, School of Medicine. Patras. GR
  • Aretha, Diamanto; University of Patras. Division of Anaesthesiology and Intensive Care Medicine, School of Medicine. Patras. GR
  • Bartzavali, Christina; University of Patras. Department of Microbiology, School of Medicine. Patras. GR
  • Siapika, Argyro; University of Patras. Department of Microbiology, School of Medicine. Patras. GR
  • Marangos, Markos; University of Patras. Division of Infectious Diseases, School of Medicine. Patras. GR
  • Fligou, Fotini; University of Patras. Division of Anaesthesiology and Intensive Care Medicine, School of Medicine. Patras. GR
Braz. j. infect. dis ; 26(2): 102353, 2022. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1384114
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Background Patients with severe Coronavirus Disease 2019 (COVID-19) are treated with corticosteroids. Aim We aimed to evaluate the role of corticosteroid treatment in candidemia development during the COVID-19 pandemic. Methods This retrospective study was conducted in a Greek ICU, from 2010 to August 2021, encompassing a pre-pandemic and a pandemic period (pandemic period April 2020 to August 2021). All adult patients with candidemia were included. Results During the study period, 3,572 patients were admitted to the ICU, 339 patients during the pandemic period, of whom 196 were SARS-CoV-2-positive. In total, 281 candidemia episodes were observed in 239 patients, 114 in the pandemic period. The majority of candidemias in both periods were catheter-related (161; 50.4%). The incidence of candidemia in the pre-pandemic period was 5.2 episodes per 100 admissions, while in the pandemic period was 33.6 (p < 0.001). In the pandemic period, the incidence among COVID-19 patients was 38.8 episodes per 100 admissions, while in patients without COVID-19 incidence was 26.6 (p= 0.019). Corticosteroid administration in both periods was not associated with increased candidemia incidence. Conclusions A significant increase of candidemia incidence was observed during the pandemic period in patients with and without COVID-19. This increase cannot be solely attributed to immunosuppression (corticosteroids, tocilizumab) of severe COVID-19 patients, but also to increased workload of medical and nursing staff.


Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas Problema de saúde: Objetivo 3: Recursos humanos em saúde Base de dados: LILACS Tipo de estudo: Estudo de incidência / Estudo observacional / Fatores de risco Idioma: Inglês Revista: Braz. j. infect. dis Assunto da revista: Doenças Transmissíveis Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Grécia Instituição/País de afiliação: University of Patras/GR

Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: Agenda de Saúde Sustentável para as Américas Problema de saúde: Objetivo 3: Recursos humanos em saúde Base de dados: LILACS Tipo de estudo: Estudo de incidência / Estudo observacional / Fatores de risco Idioma: Inglês Revista: Braz. j. infect. dis Assunto da revista: Doenças Transmissíveis Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Grécia Instituição/País de afiliação: University of Patras/GR
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