Determinación de factores de riesgo a reacciones adversas a medicamentos mediante farmacovigilancia intensiva en UCI / Risk factors for adverse drug reactions in patients admitted to intensive care units
Rev. méd. Chile
; 149(9): 1258-1266, sept. 2021. ilus, graf, tab
Artigo
em Espanhol
| LILACS
| ID: biblio-1389595
Biblioteca responsável:
CL1.1
ABSTRACT
Background:
Patients hospitalized in intensive care units (ICU) are at higher risk of having adverse drug reactions (ADR).Aim:
To determine risk factors for ADR, through intensive pharmacological surveillance at the ICU. Patients andMethods:
An observational, descriptive and prospective study was made, determining risk parameters in patients who experienced ADR.Results:
Eighty-five patients were surveilled and 24 (28%) had an ADR. A total of 48 drugs responsible for at least one ADR were identified. Seventy-three percent ADR were moderate and 27% were severe. The clinical variables significantly associated with ADR were a history of allergies, a high body mass index, the reason for admission, an APACHE II score ≥ 14 points, the use of invasive mechanical ventilation and more than seven days of hospitalization. The pharmacological variables associated with ADR were polypharmacy and medication associations and combinations.Conclusions:
The identified risk factors have a great impact on pharmacokinetic and pharmacodynamic parameters, and should be considered to avoid the appearance of ADR.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Hospitalização
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
2021
Tipo de documento:
Artigo
País de afiliação:
Chile
Instituição/País de afiliação:
Pontificia Universidad Católica de Chile/CL