AGA Clinical Practice Guideline on the Pharmacological Management of Irritable Bowel Syndrome With Constipation
Gastroenterology
; 163(1)20220701.
Artigo
em Inglês
| BIGG - guias GRADE
| ID: biblio-1399537
Biblioteca responsável:
BR1.1
ABSTRACT
Irritable bowel syndrome (IBS) is a common disorder of gutbrain interaction associated with significant disease burden. This American Gastroenterological Association guideline is intended to support practitioners in decisions about the use of medications for the pharmacological management of IBS-C and is an update of a prior technical review and guideline. The Grading of Recommendations Assessment, Development and Evaluation framework was used to assess evidence and make recommendations. The technical review panel prioritized clinical questions and outcomes according to their importance for clinicians and patients and conducted an evidence review of the following agents tenapanor, plecanatide, linaclotide, tegaserod, lubiprostone, polyethylene glycol laxatives, tricyclic antidepressants, selective serotonin reuptake inhibitors, and antispasmodics. The Guideline Panel reviewed the evidence and used the Evidence-to-Decision Framework to develop recommendations. The panel agreed on 9 recommendations for the management of patients with IBS-C. The panel made a strong recommendation for linaclotide (high certainty) and conditional recommendations for tenapanor, plecanatide, tegaserod, and lubiprostone (moderate certainty), polyethylene glycol laxatives, tricyclic antidepressants, and antispasmodics (low certainty). The panel made a conditional recommendation against the use of selective serotonin reuptake inhibitors (low certainty).
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Assuntos
Texto completo:
Disponível
Coleções:
Bases de dados temática
Base de dados:
BIGG - guias GRADE
Assunto principal:
Qualidade de Vida
/
Constipação Intestinal
/
Síndrome do Intestino Irritável
Tipo de estudo:
Guia de prática clínica
/
Estudo prognóstico
Aspecto:
Preferência do paciente
Idioma:
Inglês
Revista:
Gastroenterology
Ano de publicação:
2022
Tipo de documento:
Artigo