National Brazilian survey on the outcomes of hepatitis c retreatment in patients non-responders to direct antiviral agents
Braz. j. infect. dis
; 26(4): 102388, 2022. tab
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1403879
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Background and aims:
Treatment of hepatitis C with direct antiviral agents (DAA) is associated with almost 95% of sustained virological response. However, some patients need retreatment. In Brazil, it should be done according to the Ministry of Health guidelines, frequently updated to include newly available drugs. This study aimed to conduct a national survey about the characteristics and outcomes of retreatment of hepatitis C in previously non-responders to DAAs. Patients andmethods:
Institutions from all over the country were invited to participate in a national registry for retreatment, including information about clinical and epidemiological characteristics of the patients, type and outcomes of retreatment regimens. Only patients previously treated with interferon-free regimens were included.Results:
As previous treatments the distribution was SOF/DCV (56%), SOF/SIM (22%), 3D (11%), SOF/LED (6%) and SOF/RBV (5%). For retreatment the most frequently used drugs were SOF/GP (46%), SOF/DCV (23%) and SOF/VEL (11%). From 159 patients retreated, 132/159 (83%) had complete information in the registry and among them only seven patients were non-responders (SVR of 94.6%). All retreatments were well tolerated, without any serious adverse events or interruptions.Conclusion:
The retreatment of patients previously non-responders to DAAs was associated with high rate of SVR in this sample of Brazilian patients. This finding allows us to conclude that the retreatment options available in the public health system in Brazil are effective and safe and are an important component of the strategy of elimination of hepatitis C in our country.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
LILACS
Tipo de estudo:
Guia de prática clínica
/
Pesquisa qualitativa
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Braz. j. infect. dis
Assunto da revista:
Doenças Transmissíveis
Ano de publicação:
2022
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Ambulatorio de Hepatites Virais/BR
/
Fundação de Medicina Tropical do Amazonas/BR
/
Hospital Nossa Senhora das Graças/BR
/
Hospital Português/BR
/
Ministério da Saúde/BR
/
Prefeitura de Curitiba/BR
/
Secretária Municipal de Saúde de Ribeirão Preto/BR
/
Serviço Municipal de Infectologia de Caxias do Sul/BR
/
Universidade Estadual Paulista Júlio de Mesquita Filho/BR
/
Universidade Estadual de Campinas/BR