Your browser doesn't support javascript.
loading
Prevalence and risk factors of incidental prostate cancer in certain surgeries for benign prostatic hyperplasia: A systematic review and meta-analysis
Guo, Zhenlang; He, Junwei; Huang, Lijuan; Wang, Zhaohui; Hu, Ping; Wang, Shusheng; Bai, Zunguang; Pan, Jun.
Afiliação
  • Guo, Zhenlang; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine. Department of Urology. Guangzhou. CN
  • He, Junwei; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine. Department of Urology. Guangzhou. CN
  • Huang, Lijuan; The First Affiliated Hospital of Sun Yat-Sen University. Department of Organ Transplant. Guangzhou. CN
  • Wang, Zhaohui; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine. Department of Urology. Guangzhou. CN
  • Hu, Ping; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine. Department of Urology. Guangzhou. CN
  • Wang, Shusheng; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine. Department of Urology. Guangzhou. CN
  • Bai, Zunguang; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine. Department of Urology. Guangzhou. CN
  • Pan, Jun; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine. Department of Urology. Guangzhou. CN
Int. braz. j. urol ; 48(6): 915-929, Nov.-Dec. 2022. tab, graf
Article em En | LILACS-Express | LILACS | ID: biblio-1405157
Biblioteca responsável: BR1.1
ABSTRACT
ABSTRACT

Background:

This study aimed to explore the prevalence and clinical risk factors in patients diagnosed with incidental prostate cancer (IPC) during certain surgeries (transurethral resection of the prostate [TURP], open prostatectomy [OP], and holmium laser enucleation of the prostate [HoLEP]) after clinically suspected benign prostatic hyperplasia (BPH). Materials and

Methods:

Literature search of the MEDILINE, Web of Science, Embase, and Cochrane Library databases was performed to identify eligible studies published before June 2021. Multivariate adjusted odds ratios (ORs) and associated 95% confidence intervals (CIs) of the prevalence and clinical risk factors of IPC were calculated using random or fixed-effect models.

Results:

Twenty-three studies were included in the meta-analysis. Amongst the 94.783 patients, IPC was detected in 24.715 (26.1%). Results showed that the chance of IPC detection (10%, 95% CI 0.07-4.00; P<0.001; I2=97%) in patients treated with TURP is similar to that of patients treated with HoLEP (9%, 95% CI 0.07-0.11; P<0.001; I2=81.4%). However, the pooled prevalence estimate of patients treated with OP was 11% (95% CI −0.03-0.25; P=0.113; I2=99.1%) with no statistical significance. We observed increased incidence of IPC diagnosis after BPH surgery amongst patients with higher prostate-specific antigen (PSA) level (OR 1.13, 95% CI 1.04-1.23; P=0.004; I2=89%), whereas no effect of age (OR 1.02, 95% CI 0.97-1.06; P=0.48; I2=78.8%) and prostate volume (OR 0.99, 95% CI 0.96-1.03; P=0.686; I2=80.5%) were observed.

Conclusions:

The prevalence of IPC was similar amongst patients undergoing TURP, HoLEP, and OP for presumed BPH. Interestingly, increased PSA level was the only independent predictor of increasing risk of IPC after BPH surgery rather than age and prostate volume. Hence, future research should focus on predictors which accurately foretell the progression of prostate cancer to determine the optimal treatment for managing patients with IPC after BPH surgery.
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Int. braz. j. urol Assunto da revista: UROLOGIA Ano de publicação: 2022 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Etiology_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Idioma: En Revista: Int. braz. j. urol Assunto da revista: UROLOGIA Ano de publicação: 2022 Tipo de documento: Article / Project document País de afiliação: China País de publicação: Brasil