Your browser doesn't support javascript.
loading
Effects of pre-treatment with metoprolol and diltiazem on cerebral ischemia/reperfusion-induced injuries
Sadrhaghighi, Ghazaleh; Abbaszadeh, Samin; Babataheri, Shabnam; Garjani, Alireza; Soraya, Hamid.
Afiliação
  • Sadrhaghighi, Ghazaleh; Urmia University of Medical Sciences. School of Pharmacy. Department of Pharmacology and Toxicology. Urmia. IR
  • Abbaszadeh, Samin; Urmia University of Medical Sciences. School of Pharmacy. Department of Pharmacology and Toxicology. Urmia. IR
  • Babataheri, Shabnam; Urmia University of Medical Sciences. School of Pharmacy. Department of Pharmacology and Toxicology. Urmia. IR
  • Garjani, Alireza; Tabriz University of Medical Sciences. Faculty of Pharmacy. Department of Pharmacology and Toxicology. Tabriz. IR
  • Soraya, Hamid; Urmia University of Medical Sciences. School of Pharmacy. Department of Pharmacology and Toxicology. Urmia. IR
Braz. J. Pharm. Sci. (Online) ; 58: e21086, 2022. graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1420365
Biblioteca responsável: BR1.1
ABSTRACT
Abstract Stroke is one of the most important health concerns worldwide. Calcium ions accumulation in the nerve cells and increase in the catecholamines level of the brain following cerebral ischemia/reperfusion (I/R) are accompanied by damaging effects. Therefore, the present study aimed to evaluate the effects of diltiazem, as a calcium channel blocker, and metoprolol, as a β-adrenoceptors antagonist, on I/R injury. In this study, 30 male Wistar rats were divided into control, I/R, metoprolol, diltiazem, and metoprolol plus diltiazem groups (n=6 in each). Metoprolol (1 mg/kg/day) and diltiazem (5 mg/kg/day) were injected intraperitoneally (i.p.) for 7 days before I/R induction. On day 8, the animals underwent ischemia by bilateral common carotid arteries occlusion for 20 min. Histopathological analysis showed a significant reduction in leukocyte infiltration in diltiazem, metoprolol, and diltiazem plus metoprolol treated rats compared with the I/R group (P<0.05, P<0.01, P<0.01, respectively). In addition, in all treated groups, myeloperoxidase activity and malondialdehyde levels in the brain tissue significantly declined compared with the I/R group (P<0.001). Furthermore, pre-treatment with diltiazem and metoprolol alone or in co-administration remarkably reduced infarct size following I/R (P<0.001). Overall, the results indicate the considerable neuroprotective effects of metoprolol and diltiazem in cerebral I/R.


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Irã Instituição/País de afiliação: Tabriz University of Medical Sciences/IR / Urmia University of Medical Sciences/IR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Braz. J. Pharm. Sci. (Online) Assunto da revista: Farmacologia / Terapˆutica / Toxicologia Ano de publicação: 2022 Tipo de documento: Artigo País de afiliação: Irã Instituição/País de afiliação: Tabriz University of Medical Sciences/IR / Urmia University of Medical Sciences/IR
...