Distractibility, anxiety, irritability, and agitation symptoms are associated with the severity of depressive and manic symptoms in mixed depression
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 44(6): 576-583, Nov.-Dec. 2022. tab, graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1420530
Biblioteca responsável:
BR1.1
ABSTRACT
Objective:
To explore whether there is an association between distractibility, anxiety, irritability, and agitation (DAIA) symptoms and the severity of depressive and manic symptoms.Methods:
Patients with unipolar and bipolar disorder (I and II) and mixed depression were evaluated. DAIA symptoms were assessed using previously described definitions.Results:
The full analysis set comprised 100 patients. The severity of depressive symptoms in mixed depression, assessed by Montgomery-Åsberg Depression Rating Scale (MADRS), was significantly associated with the presence of two or more DAIA symptoms in the bipolar sample, influenced mainly by anxiety. The severity of manic symptoms in mixed depression, assessed by Young Mania Rating Scale (YMRS), was significantly associated with the presence of two or more DAIA symptoms in the bipolar sample and three or four DAIA symptoms in the unipolar sample.Conclusion:
DAIA symptoms were associated with greater severity of manic symptoms in mixed depression. DAIA symptoms must be evaluated in all patients with mixed features and are associated with the severity of depressive and manic symptoms in mixed depression. Clinical trial registration ClinicalTrials.gov (NCT04123301).
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Tipo de estudo:
Estudo diagnóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2022
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
/
Espanha
Instituição/País de afiliação:
Instituto de Neurociencias, Universidad de Barcelona, LInstitut dInvestigacions Biomèdiques August Pi i Sunyer, Investigación Biomédica en Red en el Área de Salud Mental/ES
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Instituto de Psiquiatria, Faculdade de Medicina, USP/BR
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Instituto de Psiquiatria, Faculdade de Medicina, Universidade de São Paulo (USP)/BR