Clinical and laboratory differences between chromosomal and undefined causes of non-obstructive azoospermia: A retrospective study
São Paulo med. j
; São Paulo med. j;141(4): e2022281, 2023. tab
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1432444
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT BACKGROUND:
Knowledge of clinical and laboratory differences between chromosomal and undefined causes aids etiological research on non-obstructive azoospermia.OBJECTIVE:
Compare clinical and laboratory differences between men with non-obstructive azoospermia due to chromosomal anomalies versus undefined causes DESIGN ANDSETTING:
A cross-sectional retrospective study conducted at a public university hospital in Campinas (Brazil)METHODS:
All men aged 20-40 years with non-obstructive azoospermia were included in the analysis.RESULTS:
The 107 cases included 14 with Klinefelter syndrome (KS) (13%), 1 with mosaic KS, 4 with sex development disorders (2 testicular XX, 1 NR5A1 gene mutation, and 1 mild androgen insensitivity syndrome) (4%), 9 with other non-obstructive azoospermia etiologies (8%), and 79 with undefined causes. The 22 chromosomal anomaly cases (14 KS, 1 mosaic KS, 2 testicular XX, 4 sex chromosome anomalies, and 1 autosomal anomaly) were compared with the 79 undefined cause cases. The KS group had lower average testicular volume, shorter penile length, and lower total testosterone levels but greater height, arm span, serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, and gynecomastia frequency (absent in the undefined group and affecting more than half of the KS group). Patients with testicular XX DSD had LH, FSH, and penile length data intermediate between the KS and undefined cause groups, testicular volume similar to the KS group, and other data similar to the undefined group.CONCLUSION:
Clinical and laboratory data differentiate men with non-obstructive azoospermia and chromosomal anomalies, particularly KS and testicular XX, from those with undefined causes or other chromosomal anomalies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Tipo de estudo:
Etiology_studies
/
Observational_studies
Idioma:
En
Revista:
Sao Paulo Med J
/
São Paulo med. j
/
São Paulo med. j. (Online)
/
São Paulo medical journal (Impresso)
Assunto da revista:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
MEDICINA
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Ano de publicação:
2023
Tipo de documento:
Article
/
Project document
País de afiliação:
Brasil
País de publicação:
Brasil