Development and clinical application of hydrogel formulations containing papain and urea for wound healing
Braz. J. Pharm. Sci. (Online)
; 59: e201090, 2023. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1439513
Biblioteca responsável:
BR40.1
Localização: BR40.1
ABSTRACT
Abstract Hydrogels are used for wound treatment, as they may contain one or more active components and protect the wound bed. Papain is one of the active substances that have been used with this purpose, alongside urea. In this paper, carboxypolymethylene hydrogels containing papain (2% and 10% concentrations) and urea (5% concentration) were produced. Physical-chemical stability was performed at 0, 7, 15 and 30 days at 2-8ºC, 25ºC and 40ºC, as well as the rheological aspects and proteolytic activity of papain by gel electrophoresis. Clinical efficacy of the formulations in patients with lower limb ulcers was also evaluated in a prospective, single-center, randomized, double-blind and comparative clinical trial. The results showed 7-day stability for the formulations under 25ºC, in addition to approximately 100% and 15% of protein activity for 10% and 2% papain hydrogel, respectively. The rheological profile was non-Newtonian for the 10% papain hydrogel tested. There were no significant differences regarding the mean time for healing of the lesions, although 10% papain presented a better approach to be used in all types of tissue present in the wound bed.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Ureia
/
Cicatrização
/
Papaína
/
Hidrogéis
Tipo de estudo:
Ensaio clínico controlado
Idioma:
Inglês
Revista:
Braz. J. Pharm. Sci. (Online)
Assunto da revista:
Farmacologia
/
Teraputica
/
Toxicologia
Ano de publicação:
2023
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Agência Nacional de Saúde Suplementar/BR
/
Instituto Federal do Rio de Janeiro/BR
/
Universidade Federal do Rio de Janeiro/BR