Arachnids of medical importance in Brazil: main active compounds present in scorpion and spider venoms and tick saliva
J. venom. anim. toxins incl. trop. dis
; 21: 1-14, 31/03/2015. tab, ilus
Artigo
em Inglês
| LILACS, VETINDEX
| ID: biblio-1484612
Biblioteca responsável:
BR68.1
Localização: BR68.1
ABSTRACT
Arachnida is the largest class among the arthropods, constituting over 60,000 described species (spiders, mites, ticks, scorpions, palpigrades, pseudoscorpions, solpugids and harvestmen). Many accidents are caused by arachnids, especially spiders and scorpions, while some diseases can be transmitted by mites and ticks. These animals are widely dispersed in urban centers due to the large availability of shelter and food, increasing the incidence of accidents. Several protein and non-protein compounds present in the venom and saliva of these animals are responsible for symptoms observed in envenoming, exhibiting neurotoxic, dermonecrotic and hemorrhagic activities. The phylogenomic analysis from the complementary DNA of single-copy nuclear protein-coding genes shows that these animals share some common protein families known as neurotoxins, defensins, hyaluronidase, antimicrobial peptides, phospholipases and proteinases. This indicates that the venoms from these animals may present components with functional and structural similarities. Therefore, we described in this review the main components present in spider and scorpion venom as well as in tick saliva, since they have similar components. These three arachnids are responsible for many accidents of medical relevance in Brazil. Additionally, this study shows potential biotechnological applications of some components with important biological activities, which may motivate the conducting of further research studies on their action mechanisms.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
/
VETINDEX
Assunto principal:
Saliva
/
Venenos de Escorpião
/
Venenos de Aranha
/
Carrapatos
/
Animais Peçonhentos
Limite:
Animais
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
J. venom. anim. toxins incl. trop. dis
Assunto da revista:
Toxicologia
Ano de publicação:
2015
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
University of São Paulo/BR