Association of aureomycin used by intramuscular route and of chloromycetin by oral administration in the treatment of rocky mountain spotted fever: Consideration on the results obtained from the use of purified aureomycin by parenteral injection / Associação da aureomicina utilizada por via muscular e da cloromicetina por via oral, no tratamento da febre maculosa: Considerações sôbre os resultados obtidos pelo emprêgo da Aureomicina purifieada para utilização parenteral

ABSTRACT

Having verified by a great number of cases of Rocky Mountain Spotted Fever that the treatment can only be of benefit to a limited number of patients, because of the fact that it is only started rather late, the authors think that the therapeutic problem rests on the rapidity with which the disease has to be fought. In fact, the patients enter the hospital, in general, on the ninth day of the disease, and the death occurs generally on the second week of the disease. Thus they advise the association of the parenteral to the enteral route in the administration of the antibiotics. The inconveniences caused by the injection of Aureomycin, such as irritation, intense local pain, inflammation and necrosis were removed by the method introduced by J. J. Macedo, O. Haberbeck Brandão and E. Lemos Monteiro who succeeded in using the antibiotic produced for oral administration as subcutaneous injections without the occurrence of the mentioned reactions. In a series of experiences carried on by the authors in the Instituto Butantan, São Paulo, Brazil, they verified that the guinea-pigs infected by Dermacentroxenus Rickettsi, when receiving simultaneously the injection of a solution of purified Aureomycin, in a sufficiently large dosis, were not infected; if the dosis were insufficient, the disease was delayed in its development. In experimentally infected animals, the Aureomycin, injected s

RESUMO

Em colaboração com LACAZ (1948-1949), publicamos um trabalho sôbre Blastomicose tipo Jorge Lobo, considerada, hoje em dia, como forma queloideana da blastomicose sul-americana. Nessa publicação, anotamos 6 casos da referida micose, comprovados histopatológicamente. Estava já no prelo o trabalho, quando soubemos da ocorrência de um novo, em São Paulo, observado por CERRUTI e ZAMITH (1948). Elevava-se, assim, a 7 o número casos conhecidos no Brasil e comprovados Histopatológicamente.