What lies underneath: Precise classification of brain states using time-dependent topological structure of dynamics
PloS comput. biol
; 18(9): 1-20, set 6, 2022. tab, ilus, graf
Article
em En
| RSDM
| ID: biblio-1524740
Biblioteca responsável:
MZ1.1
ABSTRACT
The self-organising global dynamics underlying brain states emerge from complex recursive nonlinear interactions between interconnected brain regions. Until now, most efforts of capturing the causal mechanistic generating principles have supposed underlying stationarity, being unable to describe the non-stationarity of brain dynamics, i.e. time-dependent changes. Here, we present a novel framework able to characterise brain states with high specificity, precisely by modelling the time-dependent dynamics. Through describing a topological structure associated to the brain state at each moment in time (its attractor or 'information structure'), we are able to classify different brain states by using the statistics across time of these structures hitherto hidden in the neuroimaging dynamics. Proving the strong potential of this framework, we were able to classify resting-state BOLD fMRI signals from two classes of post-comatose patients (minimally conscious state and unresponsive wakefulness syndrome) compared with healthy controls with very high precision
Texto completo:
1
Coleções:
06-national
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MZ
Base de dados:
RSDM
Assunto principal:
Imageamento por Ressonância Magnética
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Estado Vegetativo Persistente
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Cérebro
Limite:
Female
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Humans
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Male
Idioma:
En
Revista:
PloS comput. biol
Ano de publicação:
2022
Tipo de documento:
Article