Helios + Regulatory T cell frequencies are correlated with control of viral replication and recovery of absolute CD4 T cells counts in early HIV-1 infection
BMC immunol. (Online)
; 18(1): 1-10, Dec 16. 2017. tab, graf
Artigo
em Inglês
| RDSM
| ID: biblio-1525631
Biblioteca responsável:
MZ1.1
ABSTRACT
Background:
The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation. Regulatory T cells (Tregs) have the potential to control systemic immune activation but also to suppress antigen specific T and B cell response. The co-expression of FoxP3 and Helios transcription factors, has been described for identification of highly suppressive Tregs. The aim of this study was to characterize the phenotype of classic Tregs during early HIV infection, and to assess the correlations between the frequencies and phenotype of Tregs with the plasma viral load, CD4 counts, immune activation and the frequency of antibodies reactive to HIV-1 proteins, measured by an immunochromatographic test.Results:
The relative frequency of classic Tregs cells in peripheral blood correlated positively with HIV viral load and immune activation of CD8 T cells, and inversely with absolute CD4 counts and development of anti-HIV antibodies in subjects with early HIV infection. However, the expression of Helios in classic Tregs was inversely correlated with viral replication and immune activation, and positively with recovery of CD4 T cell counts and appearance of antibodies reactive to HIV-1 proteins
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Moçambique
Base de dados:
RDSM
Assunto principal:
Replicação Viral
/
Linfócitos T CD4-Positivos
/
Infecções por HIV
/
HIV-1
/
Linfócitos T Reguladores
/
Fatores de Transcrição Forkhead
Limite:
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
África
Idioma:
Inglês
Revista:
BMC immunol. (Online)
Ano de publicação:
2017
Tipo de documento:
Artigo
Instituição/País de afiliação:
Institute of Tropical Medicine/BE
/
Instituto nacional de saude/MZ
/
Walter Reed Army Institute of Research/US