Identifying malignant mesothelioma by a pathological survey using the São Paulo state hospital cancer registry, Brazil
J. bras. pneumol
; 50(2): e20230343, 2024. tab, graf
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1558279
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Objective:
To review the pathological diagnosis of possible cases and/or hidden cases of malignant mesothelioma (MM) between 2000 and 2012 using the Hospital-Based Cancer Registry database in the state of São Paulo, Brazil.Methods:
Possible cases were retrieved by assessing the database. Inclusion criteria were being older than 30 years of age and having ICD-O-3 topography and morphology codes related to MM. A board of expert pathologists reviewed the pathology reports and requested paraffin blocks in cases that demanded revision. After staining with calretinin, D2-40, WT-1 (as positive MM markers) and Ber-EP4 and MOC31 (as negative MM markers), cases were divided and studied independently by a pair of pathologists to confirm or discard the diagnosis of MM.Results:
Our sample comprised 482 cases from 25 hospitals, and 130 needed further histological revision. We received 73 paraffin blocks with adequate material. After board analysis, there were 9 cases with a definitive diagnosis of MM, improving the diagnostic rate in 12%. Two cases of previously diagnosed MM were discarded by review.Conclusions:
Our results confirm that part of MM underdiagnosis and underreporting in Brazil is due to incomplete or mistaken pathological diagnosis.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
J. bras. pneumol
Assunto da revista:
Pneumologia
Ano de publicação:
2024
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Brasil
Instituição/País de afiliação:
A.C. Camargo Cancer Center/BR
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Faculdade de Ciências Médicas da Santa Casa de São Paulo/BR
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Fundação Jorge Duprat Figueiredo de Segurança e Medicina do Trabalho - FUNDACENTRO/BR
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Fundação Jorge Duprat Figueiredo de Segurança e Medicina do Trabalho/BR
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Fundação Oncocentro de São Paulo/BR
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Hospital Amaral Carvalho/BR
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Hospital de Câncer de Barretos/BR
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Instituto Nacional de Câncer José Alencar Gomes da Silva/BR
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Instituto de Assistência ao Servidor Público Estadual de São Paulo/BR
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Universidade de São Paulo/BR