Efectos adversos secundarios a Anfotericina B Liposomal

RESUMEN

La anfotericina B liposomal se ha utilizado en reemplazo de la anfotericina B desoxicolato para disminuir sus efectos adversos asociados, especialmente la nefrotoxicidad. Presentamos el caso de un paciente masculino de 47 años, sin enfermedad cardíaca previa, con diagnóstico de leishmaniasis visceral, que presentó miocarditis, rabdomiólisis y polineuropatía periférica posterior al tratamiento con anfotericina B liposomal. Este caso resalta la importancia de considerar los efectos adversos tras la administración de anfotericina B liposomal.

ABSTRACT

Liposomal amphotericin B has been used to replace amphotericin B deoxycholate to reduce its associated adverse effects, especially nephrotoxicity. We present the case of a 47-year-old male patient without known previous heart disease with a diagnosis of visceral leishmaniasis, who presented myocarditis, rhabdomyolysis and peripheral polyneuropathy after starting treatment with liposomal amphotericin B. This case highlights the importance of other adverse effects to consider, such as cardiotoxicity, related to the administration of liposomal amphotericin B and other effects not previously reported such as peripheral polyneuropathy.