Influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury
Acta cir. bras
; 31(11): 759-764, Nov. 2016. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-827667
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT PURPOSE:
To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury.METHODS:
Sixteen Wistar rats - split in two groups - have been used control group, receiving 3 mg/kg isotonic saline solution through caudal vein, and, the chlorpromazine group, receiving 3 mg/kg-IV of such medication. The nephrectomy of the left kidney lower third was carried out; immediately, the test-drug was administrated. After 15 minutes of test-drug administration, the renal pedicle was clamped; in 60 minutes of ischemia it was released. After 24 hours of the renal reperfusion, the rats were, once more, anesthetized and submitted to total left nephrectomy, and, afterwards, to euthanasia. Histological findings regarding ischemia have been evaluated and compared between the groups.RESULTS:
There was no statistical difference related to inferior renal pole histological analysis. Regarding 60-minute renal ischemia, chlorpromazine has statistically reduced the accrual of leucocytes within the vasa recta renis (p=0.036) and the congestion of peritubular capillaries (p=0.041). When conducting joint analysis of histological patterns, the control group showed a median score of 11 and chlorpromazine group of 5.5 (p=0.036).CONCLUSION:
Chlorpromazine significantly reduced the occurrence of secondary damage to ischemia and reperfusion process in the overall histological analysis.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Traumatismo por Reperfusão
/
Clorpromazina
/
Precondicionamento Isquêmico
/
Rim
/
Nefropatias
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2016
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Faculdade Evangélica do Paraná/BR