Association of PRKAA1 gene polymorphisms with chronic hepatitis B virus infection in Chinese Han population
Braz. j. infect. dis
; Braz. j. infect. dis;20(6): 564-568, Nov.-Dec. 2016. tab, graf
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em En
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| ID: biblio-828158
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BR1.1
ABSTRACT
ABSTRACT Objective:
Studies have indicated that AMPK play critical roles in the regulation of innate immunity and inflammatory responses. However, the role of the polymorphisms of PRKAA1 gene in immune-response to infectious organisms remains unknown. To evaluate the potential role of PRKAA1/AMPKα1 in the immune-response to HBV, we conducted this case-control study.Methods:
We recruited 276 patients (145 men and 131 women; average age, 51.6 years) with chronic HBV infection (CHB) and 303 healthy controls (166 men and 137 women; average age, 54.2 years). All the subjects were unrelated individuals of Chinese Han Population. Three SNPs of PRKAA1gene were tested.Results:
Rs1002424 polymorphism showed significant difference in the allele frequencies, but no difference in the genotype frequencies (allele p = 0.039411, OR95%CI = 0.783479 [0.621067-0.988362]; genotype p = 0.104758); rs13361707 polymorphism showed significance in allele analysis, but not in genotype analysis (allele p = 0.034749, OR95%CI = 1.284303 [1.017958-1.620335]; genotype p = 0.098027); rs3792822 polymorphism was demonstrated to have significant differences in both genotype and allele frequencies between cases and controls (allele p = 0.029286, OR95%CI= 0.741519 [0.566439-0.970716]; genotype p = 0.034560). The haplotype results showed that CTG and TCA in the rs13361707-rs1002424-rs3792822 block were significantly associated with the happening of HBV (CTG p = 0.036854, OR95%CI = 1.281 [1.015-1.617]; p = 0.030841, OR95%CI = 0.743 [0.568-0.973]).Conclusion:
These findings suggest that PRKAA1 polymorphisms may contribute to the susceptibility of chronic HBV infection in Chinese Han origin.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Polimorfismo Genético
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Hepatite B Crônica
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Predisposição Genética para Doença
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Proteínas Quinases Ativadas por AMP
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
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Humans
/
Male
Idioma:
En
Revista:
Braz. j. infect. dis
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Brasil