Antioxidant α-amylase inhibitors flavonoids from Iris germanica rhizomes
Rev. bras. farmacogn
; 27(2): 170-174, Mar.-Apr. 2017. tab, graf
Article
em En
| LILACS
| ID: biblio-843814
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT A new isoflavonoid glycoside, iridin A (9), along with eight known isoflavonoids irilone 4'-methyl ether (1), irilone (2), irisolidone (3), irigenin S (4), irigenin (5), irilone 4'-O-β-D-glucopyranoside (6), iridin S (7), and iridin (8) were separated from Iris × germanica L., Iridaceae, rhizomes. The structural elucidation of these flavonoids was achieved with the aid of extensive spectroscopic techniques and comparing with the published data. They were estimated for their α-amylase and 1,1-diphenyl-2-picrylhydrazyl inhibitory capacities. Compounds 3, 5, and 9 showed α-amylase inhibitory activities with % inhibition 70.8, 67.5, and 70.5, respectively compared to acarbose (a reference α-amylase inhibitor). Moreover, 9 exhibited moderate antioxidant activity with IC50 8.91 µM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Idioma:
En
Revista:
Rev. bras. farmacogn
Assunto da revista:
FARMACIA
Ano de publicação:
2017
Tipo de documento:
Article
País de afiliação:
Arábia Saudita
País de publicação:
Brasil