Relationship between dental factors and risk of upper aerodigestive tract cancer / Relação entre os fatores dentais e risco de cancer no trato aero-digestivo alto

ABSTRACT

We examined the relationship between dental health variables and risk of upper aerodigestive tract (UADT) cancers in a case-control study in Southern Brazil. The study population included 717 cases of cancers of the mouth, pharynx, and larynx and 1434 controls matched on age, gender, period of admission and study site. The association with dental factors was investigated by conditional logistic regression using extensive adjustment for a priori and empirical confounders, including tobacco and alcohol consumption, diet and sociodemographic variables. Lifetime use of dentures was not associated with risk of any UADT cancer, but history of oral sores secondary to ill-fitting dentures was associated with cancers of the mouth (odds ratio [OR] = 2.3, 95 per cent confidence interval [CI] 1.2-4.6) and of the pharynx (OR = 2.7, 95 per cent CI 1.1-6.2) among those using dentures...