Effects of hypothermia on lung inflammation in a rat model of meconium aspiration syndrome
Acta cir. bras
; 33(6): 483-490, June 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-949354
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Purpose:
To evaluate the effects of hypothermia treatment on meconium-induced inflammation.Methods:
Fifteen rats were instilled with human meconium (MEC, 1.5 mL/kg, 65 mg/mL) intratracheally and ventilated for 3 hours. Eight rats that were ventilated and not instilled with meconium served as a sham group. In MEC-hypothermia group, the body temperature was lowered to 33±0.5°C. Analysis of the blood gases, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α in bronchoalveolar lavage (BAL) fluid samples, and histological analyses of the lungs were performed.Results:
The BAL fluid TNF-α, IL-1β, IL-6 and IL-8 concentrations were significantly higher in the MEC-hypothermia group than in the MEC-normothermia (p < 0.001, p < 0.001, p = 0.001, p < 0.001, respectively) and sham-controlled groups (p < 0.001, p < 0.001, p < 0.001, p < 0.001, respectively).Conclusion:
Meconium-induced inflammatory cytokine production is affected by the body temperature control.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Pneumonía
Base de dados:
LILACS
Assunto principal:
Pneumonia
/
Síndrome de Aspiração de Mecônio
/
Hipotermia Induzida
Tipo de estudo:
Estudo de avaliação
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
CIRURGIA GERAL
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
University of Başkent/TR
/
University of Mersin/TR