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Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan
Pandir, Dilek; Unal, Betul; Bas, Hatice.
Afiliação
  • Pandir, Dilek; Bozok University. TR
  • Unal, Betul; Bozok University. TR
  • Bas, Hatice; Bozok University. TR
Braz. arch. biol. technol ; 59: e16150794, 2016. tab, graf
Artigo em Inglês | LILACS | ID: biblio-951383
Biblioteca responsável: BR1.1
ABSTRACT
Furan is a food and environmental contaminant and a potent carcinogen in animals. Lycopene is one dietary carotenoid found in fruits such as tomato, watermelon and grapefruit. The present study was designed to explore the protective effect of lycopene against furan-induced oxidative damage in streptozotocin (STZ)-induced diabetic rat kidney. At the end of the experimental period (28 days), we found that lycopene markedly decreased the malondialdehide (MDA) levels in the kidney, urea, uric acid and creatinine levels in the serum of furan-treated rats. The increase of histopathology in the kidney of furan-treated rats were effectively suppressed by lycopene. Furthermore, lycopene markedly restored superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in the kidney of furan-treated rats. In conclusion, these results suggested that lycopene could protect the rat kidney against furan-induced injury by improving renal function, attenuating histopathologic changes, reducing MDA production and renewing the activities of antioxidant enzymes.


Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Braz. arch. biol. technol Assunto da revista: Biologia Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Bozok University/TR

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Idioma: Inglês Revista: Braz. arch. biol. technol Assunto da revista: Biologia Ano de publicação: 2016 Tipo de documento: Artigo País de afiliação: Turquia Instituição/País de afiliação: Bozok University/TR
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