Nuclear translocation of STAT3 by in vitro metreleptin administration causes lipolysis in human primary adipocytes
Braz. arch. biol. technol
; 59: e16150605, 2016. graf
Article
em En
| LILACS
| ID: biblio-951389
Biblioteca responsável:
BR1.1
ABSTRACT
We utilized subcutaneous (SC)- and omental (OM)-derived human primary adipocytes (hPA) from obese male, and investigated whether synthetic analog of leptin, metreleptin, may regulate lipolysis via translocation of STAT3 to the nucleus. We observed that 50 ng/mL of metreleptin increases STAT3 phosphorylation in both SC- and OM-derived hPA. Importantly, we found for the first time that metreleptin is capable of trans-locating STAT3 to the nucleus and STAT3 blockade inhibits metreleptin-induced lipolysis. Our initial data provide novel insights into the role of STAT3 as probable mediator of the action of metreleptin in regulating metabolism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
Braz. arch. biol. technol
Assunto da revista:
BIOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
/
Project document
País de afiliação:
Coréia do Sul
País de publicação:
Brasil