Changes in crossover distribution along a quadrivalent in aman carrier of a reciprocal translocation t(11; 14)
Biocell
; 29(2): 195-203, ago. 2005. ilus, tab, graf
Artigo
em Inglês
| BINACIS
| ID: bin-111
Biblioteca responsável:
AR40.1
ABSTRACT
A testicu1ar biopsy from an infertile man carrying a heterozygous chromosome translocation t(ll; 14) was studied with synaptonemal complex analysis and immunolocalization of the protein MLH 1 for crossover detection. A full blockage of spermatogenesis at the spermatocyte stage was related to the presence of the translocation quadrivalents at pachytene. Only 2% of the quadrivalents showed full synapsis. Most of the spermatocytes showed asynaptic free ends that frequently mingled with the XY pair. The average number of crossovers per cell was diminished from a mean of 52.7 in controls to a mean of 48 in the patient. The difference between the number of crossovers in the quadrivalent and the normal bivalents was highly significant. The distribution of crossovers over the segment of the quadrivalent corresponding to bivalent #14 was also very different from that ofthe control. It is concluded that in this translocation, the pattern of crossovers is changed, mainly due to a synaptic hindrance in the quadrivalent, and that the spermatogenesis arrest is mainly due to the quadrivalents that interact with the XY pair
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Coleções:
Bases de dados nacionais
/
Argentina
Base de dados:
BINACIS
Assunto principal:
Espermatogênese
/
Cromossomos Humanos Par 11
/
Cromossomos Humanos Par 14
/
Infertilidade Masculina
/
Meiose
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Biocell
Ano de publicação:
2005
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidad Nacional de Buenos Aires/Argentina