Evaluation of cytotoxic potential of latex of Calotropis procera and Podophyllotoxin in Allum cepa root model
Biocell
; 30(1): 9-13, abr. 2006. ilus, tab
Article
em En
| BINACIS
| ID: bin-119278
Biblioteca responsável:
AR40.1
Localização: AR40.1
ABSTRACT
In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cyto-toxic drug cyclophosphamide and non-cytotoxic drugs cyproheptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots and mitotic activity in a dose-dependent manner. However, podophyllotoxin was more potent in this regard and produced root decay. Cyproheptadine and aspirin, on the other hand, showed a marginal effect on the root growth and mitotic activity at much higher concentrations(AU)
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Coleções:
06-national
/
AR
Base de dados:
BINACIS
Assunto principal:
Podofilotoxina
/
Cebolas
/
Citotoxinas
/
Calotropis
/
Látex
Idioma:
En
Revista:
Biocell
Ano de publicação:
2006
Tipo de documento:
Article