Cross-reactivity of anti-10kD heat shock protein antibodies in leprosy and tuberculosis patients
Medicina [B.Aires]
; 57(5): 581-6, 1997. gra, tab
Artigo
em Inglês
| BINACIS
| ID: bin-19287
Biblioteca responsável:
BR1.1
ABSTRACT
The response to recombinant 10-KD heat shock protein (HSP of Mycobacterium leprae (rML10) was evaluated by indirect ELISA in sera from leprosy patients, household contacts, tuberculosis patients and healthy controls a leprosy-endemic area in tne North East of Argentina. Some technical parameters were a analyzed within-assay and between-assay variability, dose-response curves and dectability indexed (specificity and sensitivity) of ELISA applied to measure anti-10kDa antibodies. High levels of these antibodies have already been reported in positive baciloscopy patients; herein we have also demonstrated that tuberculosis patients sera cross-react with this M. leprae antigen. This test seems to have a low sensificity for leporsy detection; it confirms that antibodies against highly conserved HSP antigens are important in the polycional response against mycobacterial epitopes in leprosy as well as in tuberculosis. (AU)
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Coleções:
Bases de dados nacionais
/
Argentina
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Hanseníase
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Doenças Negligenciadas
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Tuberculose
Base de dados:
BINACIS
Assunto principal:
Tuberculose
/
Chaperonina 10
/
Hanseníase
/
Anticorpos Antibacterianos
/
Mycobacterium leprae
/
Antígenos de Bactérias
Tipo de estudo:
Estudo diagnóstico
Limite:
Adulto
/
Idoso
/
Idoso, 80 anos ou mais
/
Humanos
Idioma:
Inglês
Revista:
Medicina [B.Aires]
Ano de publicação:
1997
Tipo de documento:
Artigo