A maternally-inherited alteration in the T cell repertoire of BALB/c mice.
Medicina [B Aires]
; 55(1): 45-7, 1995.
Artigo
em Inglês
| BINACIS
| ID: bin-37293
Biblioteca responsável:
AR2.1
ABSTRACT
A number of milk-borne exogenous mammary tumor viruses (MMTV) infect mice shortly after birth and, when expressed, produce superantigens. The expression of these superantigens mediate the progressive deletion of T cells expressing specific V beta products. Here we describe a maternally-inherited alteration in the T cell repertoire in one colony of BALB/c mice which has not been reported up to now. This alteration involves the deletion of V beta 2+ and 14+ CD4+ T cells and correlates with a high incidence of mammary tumors, suggesting the involvement of a superantigen(s) probably transmitted through an exogenous MMTV in milk.
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Base de dados:
BINACIS
Idioma:
Inglês
Revista:
Medicina [B Aires]
Ano de publicação:
1995
Tipo de documento:
Artigo