Incidencia y etiología probable de agranulocitosis tóxica en una población definida de la provincia de Buenos Aires (1963-1976). / [Incidence and probable etiology of toxic agranulocytosis in a definite population in the province of Buenos Aires (1963-1976)]

ABSTRACT

The medical records of 55 patients with toxic agranulocytosis (unrelated to radiation, anticancer drugs or known industrial toxics) were reviewed in a well defined population of the Province of Buenos Aires during 1963-1976. There were 65 episodes in 30 women and 25 men, age average 49 years. Nine patients repeated the episode by reexposure to the same drug. The annual incidence rate was 8.4 cases per million/year. Nineteen (35.5