Activity of a platelet protein kinase that phosphorylates fibrinogen and histone in Argentine hemorrhagic fever.
Acta Physiol. Pharmacol. Ther Latinoam
; 41(4): 377-86, 1991.
Artigo
em Inglês
| BINACIS
| ID: bin-38128
Biblioteca responsável:
AR1.1
ABSTRACT
The activity of a platelet protein kinase that phosphorylates the alpha-chain of fibrinogen and the exogenous substrate histone was evaluated in 28 patients with Argentine hemorrhagic fever, grouped into 13 mild, 6 moderate and 9 severe clinical forms. Blood samples were obtained before treatment with immune plasma, 4 days later and at recovery. Exogenous histone and fibrinogen phosphorylation were assayed with 25 Ci/mmol (gamma-32P)-ATP. Platelet counts and interferon (IFN) activity were performed simultaneously. Histone phosphorylation was found below normal in all patients during the acute phase of illness. This reduction was coincident with the lowest platelet count and the highest IFN titers. Fibrinogen phosphorylation was similarly reduced. Histone and fibrinogen phosphorylation were still low after 4 days of treatment, when IFN levels were almost undetectable. The low level of phosphorylation was not simply due to the reduced number of platelets and may be another evidence of a platelet abnormality in patients with Argentine hemorrhagic fever.
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Coleções:
Bases de dados nacionais
/
Argentina
Base de dados:
BINACIS
País/Região como assunto:
América do Sul
/
Argentina
Idioma:
Inglês
Revista:
Acta Physiol. Pharmacol. Ther Latinoam
Ano de publicação:
1991
Tipo de documento:
Artigo