Activación de los protooncogenes K-ras y c-erbB-2 en adenocarcinomas colónicos humanos. / [Activation of K-ras and c-erbB-2 protooncogenes in human colonic adenocarcinomas]
Acta gastroenterol. latinoam
; 31(2): 71-6, 2001 May.
Artigo
em Espanhol
| BINACIS
| ID: bin-39507
Biblioteca responsável:
AR40.1
ABSTRACT
Although data on genetic alterations leading to development of colorectal cancer are abundant, no specific genetic alteration has been demonstrated for each class of tumor. The colorectal cancer phenotype is originated from an accumulation of different genetic alterations. The nature of these alterations, their order of appearance, and their associations vary greatly from one tumor to another, suggesting that the concept of a unique model of carcinogenesis is not applicable to these tumors. The aim of the present work was to study the association between K-ras and c-erbB-2 mutations and different clinicopathological variables in fifty-four samples from adenocarcinomas of the colon. The detection of K-ras activation was performed by specific enriched PCR. The genomic differential polymerase chain reaction with the single copy reference gene was employed for the detection of c-erbB-2 gene amplification. K-ras mutations were detected in 16 cases (29.63
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Argentina
Base de dados:
BINACIS
Tipo de estudo:
Estudo prognóstico
Idioma:
Espanhol
Revista:
Acta gastroenterol. latinoam
Ano de publicação:
2001
Tipo de documento:
Artigo