Variabilidad farmacocinética de oxcarbazepina en pacientes epilépticos. / [Pharmacokinetic variability of oxcarbazepine in epileptic patients]
Medicina [B Aires]
; 60(6): 914-8, 2000.
Artigo
em Espanhol
| BINACIS
| ID: bin-39620
Biblioteca responsável:
AR2.1
ABSTRACT
The aim of this study was to analyze the population pharmacokinetics of oxcarbazepine (OCBZ) measuring the serum level of its active metabolite, monohydroxylated oxcarbazepine (MHD). We studied a group of patients with symptomatic and cryptogenic epilepsy treated with OCBZ monotherapy orally, at least for 3 weeks. The mean doses, age and weight of the patients were 17.9 +/- 7.8 mg/kg/day, 35.6 +/- 16.4 years and 70.3 +/- 19.2 kg, respectively. Blood samples were taken before the first morning dose of OCBZ and MHD levels were determined by HPLC. A linear relationship was found between OCBZ dose and MHD serum level (r = 0.844, p < 0.001). The MHD serum concentration (mg/l) can be predicted as 0.85 x OCBZ dose (mg/kg). There was a significant correlation between observed and predicted MHD concentrations for each patient. The mean MHD clearance (Cl/F) calculated was 4.05 +/- 1.69 l/h, with a coefficient variation of 41
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Argentina
Base de dados:
BINACIS
Idioma:
Espanhol
Revista:
Medicina [B Aires]
Ano de publicação:
2000
Tipo de documento:
Artigo