Proteolytic activities in kidney and liver during refeeding of protein depleted mice.
Acta Physiol. Pharmacol. Latinoam
; 39(3): 235-44, 1989.
Artigo
em Inglês
| BINACIS
| ID: bin-51957
Biblioteca responsável:
AR1.1
ABSTRACT
Proteolytic activities at pH 5.0 and pH 7.4 in both kidney and liver during refeeding of protein-depleted mice were determined. Under this nutritional condition, the in vivo rate of protein breakdown is inhibited. Protein depletion caused in both kidney and liver a loss of pH 5.0 proteolytic activity. It was restored to normal values after 12 hours of refeeding with a complete diet. The pH 7.4 proteolytic activity also decreased as a consequence of protein depletion, but remained low during refeeding. Both re-fed kidney and liver lysosomes showed an increased stability to osmotic shock and, therefore, a decreased autophagic activity. The results indicate that both kidney and liver exhibit a similar behavior. The decreased activity of the lysosomal-vacuolar system, and the low pH 7.4 proteolytic activity may account for the observed in vivo protein breakdown inhibition during refeeding of protein-depleted mice.
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Argentina
Base de dados:
BINACIS
Idioma:
Inglês
Revista:
Acta Physiol. Pharmacol. Latinoam
Ano de publicação:
1989
Tipo de documento:
Artigo